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Registered: 12-2017
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Stanford scientists start company to de age human cells. NYT


https://www.nytimes.com/2020/03/24/science/aging-dna-epigenetics-cells.html
3/30/2020, 8:09 am Link to this post PM richiemobile Blog
 
greendocnowciv Profile
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Registered: 11-2017
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Re: Stanford scientists start company to de age human cells. NYT


Very exciting, Rich! Thanks.

But the NY Times site doesn't like me. So here's a bit from the research article that NY Times article is based on:


"Old human cells return to a more youthful and vigorous state after being induced to briefly express a panel of proteins involved in embryonic development, according to a new study by researchers at the Stanford University School of Medicine.

The researchers also found that elderly mice regained youthful strength after their existing muscle stem cells were subjected to the rejuvenating protein treatment and transplanted back into their bodies.

The proteins, known as Yamanaka factors, are commonly used to transform adult cells into induced pluripotent stem cells, or iPS cells.

Induced pluripotent stem cells can become nearly any type of cell in the body, regardless of the cell from which they originated. They’ve become important in regenerative medicine and drug discovery.

The study found that inducing old human cells in a lab dish to briefly express these proteins rewinds many of the molecular hallmarks of aging and renders the treated cells nearly indistinguishable from their younger counterparts.

“When iPS cells are made from adult cells, they become both youthful and pluripotent,” said Vittorio Sebastiano, PhD, assistant professor of obstetrics and gynecology and the Woods Family Faculty Scholar in Pediatric Translational Medicine.

“We’ve wondered for some time if it might be possible to simply rewind the aging clock without inducing pluripotency. Now we’ve found that, by tightly controlling the duration of the exposure to these protein factors, we can promote rejuvenation in multiple human cell types.”

Sebastiano is the senior author of the study, which will be published online March 24 in Nature Communications. Former graduate student Tapash Sarkar, PhD, is the lead author of the article.

“We are very excited about these findings,” said study co-author Thomas Rando, MD, PhD, professor of neurology and neurological sciences and the director of Stanford’s Glenn Center for the Biology of Aging.

“My colleagues and I have been pursuing the rejuvenation of tissues since our studies in the early 2000s revealed that systemic factors can make old tissues younger. In 2012, Howard Chang and I proposed the concept of using reprogramming factors to rejuvenate cells and tissues, and it is gratifying to see evidence of success with this approach.”

http://med.stanford.edu/news/all-news/2020/03/old-human-cells-rejuvenated-with-stem-cell-technology.html

~~~~~~~~~~

This looks like a treatment right now!

A company called Bioviva lets customers do stuff like this this, in the sense of trying some treatment that is very far from US approval as treatment. They do so this way:

They call you getting whatever the unaproved treatement is, a study.

You are the lucky first (or other, if the treatment catches on) to get "whatever" treatment.

If they pick this up, I'd wait until my stuff picks back up in stock value, and sell much of it to be a "Study patient."

Oh yeah - their profits come in, as well as the costs of treatment, by charging the "research volunteer" a "research fee" by whatever cute name they call it.

They also stay out of the US to avoid any Feds nosing in and shutting them down.

3/30/2020, 5:11 pm Link to this post PM greendocnowciv Blog
 


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